49ers Vs Steelers 2025 Predictions. The 49ers defense will be too much to handle for jones and company as the 49ers win their home opener on thursday night football. View the 2025 pittsburgh steelers football schedule at fbschedules.com.

Nick bosa and brock purdy vs. With the 49ers’ 2024 playoff hopes all but faded, the focus now turns toward san francisco’s 2025 nfl draft positioning.